﻿{"id":100,"date":"2015-12-19T06:00:44","date_gmt":"2015-12-19T06:00:44","guid":{"rendered":"http:\/\/www.ana-log.org\/signaladvance\/?page_id=100"},"modified":"2021-03-17T02:02:35","modified_gmt":"2021-03-17T02:02:35","slug":"validation","status":"publish","type":"page","link":"https:\/\/www.signaladvance.com\/?page_id=100","title":{"rendered":"Overview &#8211; Validation"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|desktop&#8221; admin_label=&#8221;section&#8221; _builder_version=&#8221;3.22&#8243; background_color=&#8221;#ffffff&#8221; custom_padding_tablet=&#8221;50px|0|50px|0&#8243; custom_padding_phone=&#8221;&#8221; transparent_background=&#8221;off&#8221; padding_mobile=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221;][et_pb_row admin_label=&#8221;Row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_divider color=&#8221;#305b68&#8243; disabled_on=&#8221;on|on|off&#8221; admin_label=&#8221;Divider&#8221; _builder_version=&#8221;3.2&#8243; hide_on_mobile=&#8221;on&#8221;] [\/et_pb_divider][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;3.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<h3><strong><span style=\"color: #008080;\">Scientific\u00a0Validation<\/span><\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; admin_label=&#8221;row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;3.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]In Dr. Hymel\u2019s doctoral dissertation study, SA circuit designs, developed specifically for electrocardiology, the electrical functioning of the heart, underwent rigorous refinement, testing and evaluation. In the study, the \u2018negative delay\u2019 (temporal advance) of the analog signals achieved with SAT was investigated and the results analyzed with respect to the temporal advance achieved as well as the fidelity of the temporally-advanced output signals. The research project, completed in 2010, exceeded all of its objectives, having successfully demonstrated the ability of SAT to temporally advance a range \u2018known\u2019 constructed test signals (pulses and sine waves) and human electrocardiographic (ECG) signals (heart beats) from cardiac patients. The project resulted in a doctorate dissertation\u00a0<a href=\"http:\/\/digitalcommons.library.tmc.edu\/utgsbs_dissertations\/74\/\" target=\"_blank\" rel=\"noopener noreferrer\">(Hymel CM, Application of Signal Advance Technology to Electrophysiology, University of Texas Health Science Center \u2013 Houston, Graduate School of Biomedical Sciences, August 2010)<\/a>,\u00a0which was downloaded over 300 times in the first three years following its release. <a href=\"https:\/\/www.signaladvance.com\/wp-content\/uploads\/2016\/01\/Dissertation-Signal-Advance-Applied-to-Electrophysiology-C-Hymel.pdf\">Download dissertation<\/a><br \/>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_gallery gallery_ids=&#8221;675,676,677,678,679&#8243; fullwidth=&#8221;on&#8221; admin_label=&#8221;Gallery&#8221; _builder_version=&#8221;3.0.87&#8243; caption_all_caps=&#8221;off&#8221; auto=&#8221;on&#8221; auto_speed=&#8221;4000&#8243; border_width_all=&#8221;1px&#8221; border_color_all=&#8221;#ffffff&#8221; border_style_all=&#8221;solid&#8221; use_border_color=&#8221;on&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;] [\/et_pb_gallery][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=&#8221;Row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_divider color=&#8221;#305b68&#8243; disabled_on=&#8221;on|on|off&#8221; admin_label=&#8221;Divider&#8221; _builder_version=&#8221;3.2&#8243; hide_on_mobile=&#8221;on&#8221;] [\/et_pb_divider][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;3.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; text_orientation=&#8221;right&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<h3><strong><span style=\"color: #008080;\">Technical\u00a0Validation<\/span><\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; admin_label=&#8221;row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;http:\/\/www.ana-log.org\/signaladvance\/wp-content\/uploads\/2015\/12\/ieee_casm_article-cover.jpg&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; admin_label=&#8221;Image&#8221; _builder_version=&#8221;3.23&#8243; animation_style=&#8221;slide&#8221; animation_direction=&#8221;left&#8221; animation_duration=&#8221;500ms&#8221; animation_intensity_slide=&#8221;10%&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; animation=&#8221;left&#8221; sticky=&#8221;off&#8221; always_center_on_mobile=&#8221;on&#8221;] [\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;3.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<p id=\"u498-2\">The results of the study were summarized in a peer-reviewed engineering article which discusses the theoretical basis, practical implementation and examples of potential applications for SA technology. The manuscript, submitted for review in March 2011, was published as the feature article in the IEEE Circuits and Systems Magazine, in the 3rd Qtr.<\/p>\n<p id=\"u498-10\"><span id=\"u498-4\"><span id=\"u498-7\"><span id=\"u498-5\">Hymel et al, IEEE Circuits and Systems Magazine, 3Q, 11 (3), 10-25<\/span><\/span><span id=\"u498-8\">.<\/span><\/span><\/p>\n<ul>\n<li><a href=\"http:\/\/ieeexplore.ieee.org\/xpl\/login.jsp?tp=&amp;arnumber=5995855&amp;url=http%3A%2F%2Fieeexplore.ieee.org%2Fiel5%2F7384%2F5995850%2F05995855.pdf%3Farnumber%3D5995855\" target=\"_blank\" rel=\"noopener noreferrer\"><span id=\"u498-4\">Access to article in\u00a0<\/span><span id=\"u498-7\"><span id=\"u498-5\">IEEE Circuits and Systems Magazine<\/span><\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.signaladvance.com\/wp-content\/uploads\/2016\/01\/Hymel-etal-IEEE-CASM-Paper-Submit-030711.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Article submission download<\/a><\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|desktop&#8221; admin_label=&#8221;section&#8221; _builder_version=&#8221;3.22&#8243; background_color=&#8221;#ffffff&#8221; custom_padding_tablet=&#8221;50px|0|50px|0&#8243; custom_padding_phone=&#8221;&#8221; transparent_background=&#8221;off&#8221; padding_mobile=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221;][et_pb_row admin_label=&#8221;Row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_divider color=&#8221;#305b68&#8243; disabled_on=&#8221;on|on|off&#8221; admin_label=&#8221;Divider&#8221; _builder_version=&#8221;3.2&#8243; hide_on_mobile=&#8221;on&#8221;] [\/et_pb_divider][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.0.9&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; text_orientation=&#8221;right&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<h3 style=\"text-align: left;\"><strong><span style=\"color: #008080;\">Signal Advance Technology<\/span><\/strong><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; admin_label=&#8221;row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.0.9&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<p id=\"u498-2\">Signal Advance Technology Document<\/p>\n<p>In recent years, a physical phenomenon referred to as Negative Group Delay (NGD), demonstrated in simple electronic circuits, has been shown to temporally advance the detection of analog waveforms. Specifically, the output is advanced in time relative to the input, as the time delay through the circuit is negative. As such, the circuit output precedes the complete detection of the input signal. We refer to this as Signal Advance (SA) technology. Success in the development and implementation of this technology has important consequences for the development of novel interventional methodologies in cardiology and neurophysiology as well as significant potential in a broader range of both medical and non-medical areas of application.<\/p>\n<p id=\"u498-10\"><span id=\"u498-4\"><span id=\"u498-7\"><span id=\"u498-5\">Author: Dr. C. Hymel<\/span><\/span><\/span><\/p>\n<ul>\n<li><a href=\"https:\/\/www.signaladvance.com\/wp-content\/uploads\/2021\/03\/Signal Advance Technology.pdf\">Signal Advance Technology<\/a><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image _builder_version=&#8221;4.0.9&#8243; src=&#8221;https:\/\/www.signaladvance.com\/wp-content\/uploads\/2021\/03\/Signal-Advance-Technology-PDF-Image.png&#8221; hover_enabled=&#8221;0&#8243;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|desktop&#8221; admin_label=&#8221;section&#8221; _builder_version=&#8221;3.22&#8243; background_color=&#8221;#ffffff&#8221; custom_padding_tablet=&#8221;50px|0|50px|0&#8243; custom_padding_phone=&#8221;&#8221; transparent_background=&#8221;off&#8221; padding_mobile=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221;][et_pb_row admin_label=&#8221;Row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_divider color=&#8221;#305b68&#8243; disabled_on=&#8221;on|on|off&#8221; admin_label=&#8221;Divider&#8221; _builder_version=&#8221;3.2&#8243; hide_on_mobile=&#8221;on&#8221;] [\/et_pb_divider][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;3.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;] Scientific\u00a0Validation [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; admin_label=&#8221;row&#8221; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;3.27.4&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=\/wp\/v2\/pages\/100"}],"collection":[{"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=100"}],"version-history":[{"count":32,"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=\/wp\/v2\/pages\/100\/revisions"}],"predecessor-version":[{"id":1418,"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=\/wp\/v2\/pages\/100\/revisions\/1418"}],"wp:attachment":[{"href":"https:\/\/www.signaladvance.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=100"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}